Molecular MRI of atherosclerotic plaque with targeted contrast agents
نویسندگان
چکیده
منابع مشابه
Two-compartment pharmacokinetic modeling of targeted molecular MRI contrast agents
Introduction Molecular MRI allows the specific detection of biomolecules that are upregulated during disease. To this extent, contrast agents (CAs) are used that home to the targeted biomolecules via high affinity ligands coupled to the CA. Activated endothelial cells in tumor angiogenesis provide well suited disease markers, which are easily accessible for circulating CAs. Several studies have...
متن کاملMolecular imaging with targeted contrast agents.
Molecular imaging with targeted contrast agents by magnetic resonance imaging (MRI) allows for the noninvasive detection and characterization of biological changes on a molecular level. In this article, the principles of molecular MRI and its applications in cardiovascular diseases are reviewed. First, basic properties of positive and negative contrast agents are introduced and their effect on ...
متن کاملDynamic Contrast-Enhanced MRI to Study Atherosclerotic Plaque Microvasculature
Rupture of a vulnerable atherosclerotic plaque of the carotid artery is an important underlying cause of clinical ischemic events, such as stroke. Abundant microvasculature has been identified as an important aspect contributing to plaque vulnerability. Plaque microvasculature can be studied non-invasively with dynamic contrast-enhanced (DCE-)MRI in animals and patients. In recent years, severa...
متن کاملMolecular MRI of murine atherosclerotic plaque targeting NGAL: a protein associated with unstable human plaque characteristics.
AIMS Neutrophil gelatinase-associated lipocalin (NGAL) is an effector molecule of the innate immune system. One of its actions is the prolongation of matrix metalloproteinase-9 (MMP-9) activity by the formation of a degradation-resistant NGAL/MMP-9 complex. We studied NGAL in human atherosclerotic lesions and we examined whether NGAL could act as a target for molecular imaging of atheroscleroti...
متن کاملMolecular MRI of atherosclerotic plaque progression in an ApoE(-/-) mouse model with a CLT1 peptide targeted macrocyclic Gd(III) chelate.
Molecular imaging of atherosclerotic biomarkers is critical for non-invasive detection and diagnosis of atherosclerotic plaques and therapeutic management. Fibrin and fibronectin accumulate at elevated levels in atherosclerotic plaques and are associated with atherogenesis and disease progression. Molecular imaging of these biomarkers has the potential to non-invasively characterize plaque burd...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Current Cardiovascular Imaging Reports
سال: 2009
ISSN: 1941-9066,1941-9074
DOI: 10.1007/s12410-009-0012-y